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HRID732456

反应详情

EQUATION

反应方程式

HRID 732456 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：CCOC(=O)c1cc(N[C@@H](C)CC)nc(OC(F)F)c1
HCID68814656

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@H](C)Nc1cc(C(=O)O)cc(OC(F)F)n1
HCID68815507

未命名化合物

收率 85%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Add 2 N NaOH (0.67 mL) to (S)-2-sec-butylamino-6-difluoromethoxy-isonicotinic acid ethyl ester in ethanol (5 mL). Stir 3 h and acidify to about pH=4 with 1 N HCl and extract with ethyl acetate. Wash organic layer with saturated aqueous sodium chloride, dry (magnesium sulfate) and concentrate to give the title compound (0.1 g, 85%).

WORKUP

后处理

  1. extractionextract with ethyl acetate
  2. dry with materialWash organic layer with saturated aqueous sodium chloride, dry (magnesium sulfate)
  3. concentrationconcentrate