反应详情

Stir a solution of N-methyl-5-oxazol-2-yl-N-propyl-isophthalamic acid methyl ester (225 mg, 0.74 mmol) in 1 N lithium hydroxide (3.0 mL, 3.0 mmol) and THF (3.0 mL) at room temperature for 3 h. Add water (40 mL) and extract with ethyl acetate (40 mL). Acidify the aqueous with 5 N HCl, extract with ethyl acetate (2×40 mL), dry (magnesium sulfate) and concentrate to give the title compound (213 mg, 100%).

1. extractionAdd water (40 mL) and extract with ethyl acetate (40 mL)
2. extractionextract with ethyl acetate (2×40 mL)
3. dry with materialdry (magnesium sulfate)
4. concentrationconcentrate