反应详情

Dissolve 5-(difluorofuran-2-yl-methyl)-N-methyl-N-propyl-isophthalamic acid methyl ester (30 mg, 0.08 mmol) in methanol (2 mL). Add dropwise 2 N NaOH (0.06 mL) and stir overnight at room temperature. Acidify the mixture to about pH=6 with 5 N HCl and concentrate to near dryness. Dilute the residue with ethyl acetate, wash with saturated aqueous sodium chloride solution, dry (magnesium sulfate) and concentrate to give the title compound (66%).

1. concentrationconcentrate to near dryness
2. additionDilute the residue with ethyl acetate
3. washwash with saturated aqueous sodium chloride solution
4. dry with materialdry (magnesium sulfate)
5. concentrationconcentrate