反应详情

Dissolve 5-isobutyryl-N-methyl-N-propyl-isophthalamic acid methyl ester (50 mg, 0.16 mmol) in methanol (3 mL) and add dropwise 2 N NaOH (0.16 mL). Stir the mixture at room temperature for 6 h, store overnight at 4° C. and acidify to about pH=6 by 5 N HCl. Concentrate to near dryness and dilute the residue with ethyl acetate. Wash with saturated aqueous sodium chloride solution and extract the organic layer, dry (magnesium sulfate) and concentrate to give the title compound.

1. waitstore overnight at 4° C.
2. concentrationConcentrate
3. additiondilute the residue with ethyl acetate
4. washWash with saturated aqueous sodium chloride solution
5. extractionextract the organic layer
6. dry with materialdry (magnesium sulfate)
7. concentrationconcentrate