反应详情

温度

0 °C

Treat a solution of 5-formyl-N-methyl-N-propyl-isophthalamic acid ethyl ester (400 mg, 1.44 mmol) in THF (10 mL) at 0° C. with methylmagnesium bromide (3.0 M in diethyl ether, 0.58 mL, 1.73 mmol). Stir at 0° C. for 1 h and quench with saturated aqueous ammonium chloride solution. Extract with ethyl acetate (100 mL), dry (magnesium sulfate), concentrate and purify (silica gel chromatography, eluting with 40:60 to 70:30 ethyl acetate:hexanes) to give the title compound (250 mg, 59%).

1. customquench with saturated aqueous ammonium chloride solution
2. extractionExtract with ethyl acetate (100 mL)
3. dry with materialdry (magnesium sulfate)
4. concentrationconcentrate
5. custompurify
6. wash(silica gel chromatography, eluting with 40:60 to 70:30 ethyl acetate:hexanes)