Hydrochloric Acid → HCID 68814459, compound

HRID 732571Notes

Reaction equation

HRID 732571 reaction equation
[CH3:1][O:2][C:3](=[O:18])[C:4]1[CH:13]=[C:12]([O:14][CH:15]([F:17])[F:16])[CH:11]=[C:6]([C:7]([O:9]C)=[O:8])[CH:5]=1.[OH-].[Na+].Cl>CO>[CH3:1][O:2][C:3](=[O:18])[C:4]1[CH:13]=[C:12]([O:14][CH:15]([F:16])[F:17])[CH:11]=[C:6]([C:7]([OH:9])=[O:8])[CH:5]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68815247HCID 68815247, compound

Product 1

HCID 68814459HCID 68814459, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Treat a solution of 5-difluoromethoxy-isophthalic acid dimethyl ester (2.7 g, 10.4 mmol) in methanol (35 mL) with 2 N NaOH (5.2 mL, 10.4 mmol) at room temperature for 12 h. Acidify to about pH=3 using 5 N HCl. Extract with ethyl acetate, wash the organic layer with water, saturated aqueous sodium chloride, dry (sodium sulfate) and concentrate to give the crude title product which is used in the next step without further purification.

Workup

  1. extractionExtract with ethyl acetate
  2. washwash the organic layer with water, saturated aqueous sodium chloride
  3. dry with materialdry (sodium sulfate)
  4. concentrationconcentrate

Sources & evidence

ORD record
ord-a4fb10c64fd74cdea92ddf1564bdef26
Source dataset
uspto-grants-2009_09
Patent number
US07585885B2

Reaction notes

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