Hydrochloric Acid → HCID 68814674, compound

HRID 732605Notes

Reaction equation

HRID 732605 reaction equation
C(OC([N:8]1[CH2:12][CH:11]([CH2:13][C:14]([OH:16])=[O:15])[CH2:10][C@@H:9]1[C@H:17]1[O:21]C(C)(C)[N:19]([C:24](=[O:26])[CH3:25])[C@H:18]1[CH2:27][C:28]1[CH:33]=[C:32]([F:34])[CH:31]=[C:30]([F:35])[CH:29]=1)=O)(C)(C)C.[ClH:36]>>[ClH:36].[C:24]([NH:19][C@@H:18]([CH2:27][C:28]1[CH:29]=[C:30]([F:35])[CH:31]=[C:32]([F:34])[CH:33]=1)[C@@H:17]([CH:9]1[NH:8][CH2:12][C@@H:11]([CH2:13][C:14]([OH:16])=[O:15])[CH2:10]1)[OH:21])(=[O:26])[CH3:25]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 68814269HCID 68814269, compound

Product 1

HCID 68814674HCID 68814674, compoundYield 105.9%

Procedure

Combine (R)-2-[(4S,5S)-3-Acetyl-4-(3,5-difluoro-benzyl)-2,2-dimethyl-oxazolidin-5-yl]-4-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (0.05 g, 0.101 mmol) and HCl (4M in dioxane, 1.88 mL, 7.55 mmol). Stir overnight. Concentrate under reduced pressure to provide the title compound (0.042 g, 92%).

Workup

  1. concentrationConcentrate under reduced pressure

Sources & evidence

ORD record
ord-50efc3c0e99c4ee1ac2dd4fd7f7001da
Source dataset
uspto-grants-2009_09
Patent number
US07585885B2

Reaction notes

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