HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Bicarbonate → HCID 68818146, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Bicarbonate | HCID 14013 | — |
| Reactant | HCID 68816170 | HCID 68816170 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 68818146 | HCID 68818146 | — |
Reaction Steps
Subject mixture of Z and E isomers of (R)-2-[(4S,5S)-3-acetyl-4-(3,5-difluoro-benzyl)-2,2-dimethyl-oxazolidin-5-yl]-4-[1-methoxycarbonyl-methylidene]-pyrrolidine-1-carboxylic acid tert-butyl ester to reverse phase HPLC under basic conditions with aqueous ammonium bicarbonate (10 mM) at pH 8, Isocratic mode: 67% CH3CN. Retention time 3.7 (isomer E) and 4.1 min (isomer Z).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585885B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-2d66efc5274c4e86a6d2fac7116a4b65 |
| Source note | uspto-grants-2009_09 |