Ammonium Bicarbonate → HCID 68818146, compound

HRID 732607Notes

Reaction equation

HRID 732607 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][C:11](=[CH:13][C:14]([O:16][CH3:17])=[O:15])[CH2:10][C@@H:9]1[C@H:18]1[O:22][C:21]([CH3:24])([CH3:23])[N:20]([C:25](=[O:27])[CH3:26])[C@H:19]1[CH2:28][C:29]1[CH:34]=[C:33]([F:35])[CH:32]=[C:31]([F:36])[CH:30]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(=O)(O)[O-].[NH4+]>CC#N>[C:1]([O:5][C:6]([N:8]1[CH2:12]/[C:11](=[CH:13]\[C:14]([O:16][CH3:17])=[O:15])/[CH2:10][C@@H:9]1[C@H:18]1[O:22][C:21]([CH3:24])([CH3:23])[N:20]([C:25](=[O:27])[CH3:26])[C@H:19]1[CH2:28][C:29]1[CH:34]=[C:33]([F:35])[CH:32]=[C:31]([F:36])[CH:30]=1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 14013Ammonium BicarbonateHCID 68816170HCID 68816170, compound

Product 1

HCID 68818146HCID 68818146, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Subject mixture of Z and E isomers of (R)-2-[(4S,5S)-3-acetyl-4-(3,5-difluoro-benzyl)-2,2-dimethyl-oxazolidin-5-yl]-4-[1-methoxycarbonyl-methylidene]-pyrrolidine-1-carboxylic acid tert-butyl ester to reverse phase HPLC under basic conditions with aqueous ammonium bicarbonate (10 mM) at pH 8, Isocratic mode: 67% CH3CN. Retention time 3.7 (isomer E) and 4.1 min (isomer Z).

Workup

  1. customRetention time 3.7 (isomer E) and 4.1 min (isomer Z)

Sources & evidence

ORD record
ord-2d66efc5274c4e86a6d2fac7116a4b65
Source dataset
uspto-grants-2009_09
Patent number
US07585885B2

Reaction notes

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