Hydrochloric Acid → HCID 68818010, compound

HRID 732614Notes

Reaction equation

HRID 732614 reaction equation
[ClH:1].C(OC([N:9]1[CH2:13][C@H:12]([O:14][CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:11][C@@H:10]1[C@H:20]1[O:24]C(C)(C)[N:22]([C:27](=[O:29])[CH3:28])[C@H:21]1[CH2:30][C:31]1[CH:36]=[C:35]([F:37])[CH:34]=[C:33]([F:38])[CH:32]=1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[F:37][C:35]1[CH:36]=[C:31]([CH:32]=[C:33]([F:38])[CH:34]=1)[CH2:30][C@H:21]([NH:22][C:27](=[O:29])[CH3:28])[C@H:20]([OH:24])[C@H:10]1[CH2:11][C@@H:12]([O:14][CH2:15][CH2:16][CH:17]([CH3:18])[CH3:19])[CH2:13][NH:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68815253HCID 68815253, compound

Product 1

HCID 68818010HCID 68818010, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Add 4M hydrogen chloride in dioxane (8 mL) to (2R,4R)-2-[(4S,5S)-3-acetyl-4-(3,5-difluoro-benzyl)-2,2-dimethyl-oxazolidin-5-yl]-4-(3-methyl-butoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester (0.079 g, 0.15 mmol). Stir 2 hours and evaporate to give the title compound as a foam (0.089 g, 100%).

Workup

  1. customevaporate

Sources & evidence

ORD record
ord-2c8734a88d034fdb9d542344823f4b32
Source dataset
uspto-grants-2009_09
Patent number
US07585885B2

Reaction notes

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