Hydrochloric Acid → HCID 68814842, compound

HRID 732615Notes

Reaction equation

HRID 732615 reaction equation
[ClH:1].C(OC([N:9]1[CH2:13][C@H:12]([O:14][CH2:15][CH:16]([OH:21])[C:17]([OH:20])([CH3:19])[CH3:18])[CH2:11][C@@H:10]1[C@H:22]1[O:26]C(C)(C)[N:24]([C:29](=[O:31])[CH3:30])[C@H:23]1[CH2:32][C:33]1[CH:38]=[C:37]([F:39])[CH:36]=[C:35]([F:40])[CH:34]=1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[F:39][C:37]1[CH:38]=[C:33]([CH:34]=[C:35]([F:40])[CH:36]=1)[CH2:32][C@H:23]([NH:24][C:29](=[O:31])[CH3:30])[C@@H:22]([C@H:10]1[CH2:11][C@@H:12]([O:14][CH2:15][CH:16]([OH:21])[C:17]([OH:20])([CH3:19])[CH3:18])[CH2:13][NH:9]1)[OH:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68815322HCID 68815322, compound

Product 1

HCID 68814842HCID 68814842, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Add 4M hydrogen chloride in dioxane (5 mL) to (2R,4R)-2-[(4S,5S)-3-acetyl-4-(3,5-difluoro-benzyl)-2,2-dimethyl-oxazolidin-5-yl]-4-(2,3-dihydroxy-3-methyl-butoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester (0.07 g, 0.126 mmol). Stir 4 hours and evaporate to give the title compound as a foam (0.062 g, 100%).

Workup

  1. customevaporate

Sources & evidence

ORD record
ord-ec49503c07fb4f4297ccd8c2629ec093
Source dataset
uspto-grants-2009_09
Patent number
US07585885B2

Reaction notes

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