Hydrochloric Acid → HCID 86615022, compound

HRID 732618Notes

Reaction equation

HRID 732618 reaction equation
[ClH:1].C(OC([N:9]1[CH2:13][C@@:12]([O:18][CH2:19][CH2:20][CH:21]([CH3:23])[CH3:22])([C:14]([F:17])([F:16])[F:15])[CH2:11][C@@H:10]1[C@H:24]1[O:28]C(C)(C)[N:26]([C:31](=[O:33])[CH3:32])[C@H:25]1[CH2:34][C:35]1[CH:40]=[C:39]([F:41])[CH:38]=[C:37]([F:42])[CH:36]=1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[F:41][C:39]1[CH:40]=[C:35]([CH:36]=[C:37]([F:42])[CH:38]=1)[CH2:34][C@H:25]([NH:26][C:31](=[O:33])[CH3:32])[C@H:24]([OH:28])[C@H:10]1[CH2:11][C@:12]([O:18][CH2:19][CH2:20][CH:21]([CH3:22])[CH3:23])([C:14]([F:17])([F:15])[F:16])[CH2:13][NH:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68815503HCID 68815503, compound

Product 1

HCID 86615022HCID 86615022, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Add 4M hydrogen chloride in dioxane (8 mL) to (2R,4R)-2-[(4S,5S)-3-acetyl-4-(3,5-difluoro-benzyl)-2,2-dimethyl-oxazolidin-5-yl]-4-(3-methyl-butoxy)-4-trifluoromethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (0.084 g, 0.14 mmol). Stir 2 hours and evaporate to give the title compound as a foam (0.073 g, 100%).

Workup

  1. customevaporate

Sources & evidence

ORD record
ord-82007274f8bd4801b9fd1d4da6c6fdf9
Source dataset
uspto-grants-2009_09
Patent number
US07585885B2

Reaction notes

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