HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-Bromo-6-methoxynaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 6-Methoxy-2-naphthol | HCID 288634 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Bromo-6-methoxynaphthalen-2-ol | HCID 18428746 | 87.8% |
Reaction Steps
Add 6-methoxynaphthalene-2-ol (20 g, 114.8 mmol) to dimethylformamide (DMF, 250 mL) at ambient temperature followed by N-bromosuccinimide (NBS 21.5 g, 120 mmol) over a 30 minute period. After 45 minutes, dilute with water (800 n-L), collect and dry the precipitate to provide 25.5 g (87%) of 1-bromo-6-methoxy-naphthalen-2-ol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585977B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-107640c4ec2644a18797f416cb4718de |
| Source note | uspto-grants-2009_09 |