Hydrochloric Acid → HCID 68518345, compound

HRID 732741Notes

Reaction equation

HRID 732741 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:12]([O:31][C:32]3[CH:37]=[CH:36][C:35]([O:38][CH2:39][CH2:40][N:41]4[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]4)=[CH:34][CH:33]=3)=[C:13]3[C:18](=[CH:19][CH:20]=2)[CH:17]=[C:16]([O:21][C:22](=[O:30])[C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)[CH:15]=[CH:14]3)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[ClH:47].CCOCC>ClCCl>[ClH:47].[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([C:11]2[C:12]([O:31][C:32]3[CH:37]=[CH:36][C:35]([O:38][CH2:39][CH2:40][N:41]4[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]4)=[CH:34][CH:33]=3)=[C:13]3[C:18](=[CH:19][CH:20]=2)[CH:17]=[C:16]([O:21][C:22](=[O:30])[C:23]2[CH:24]=[CH:25][C:26]([F:29])=[CH:27][CH:28]=2)[CH:15]=[CH:14]3)=[CH:9][CH:10]=1)(=[O:3])=[O:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 59751437HCID 59751437, compound

Product 1

HCID 68518345HCID 68518345, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Dissolve the compound of Example 7 (99 mg, 0.15 mmol) in dichloromethane (3 mL) and add 2M HCl in ether (400 μL, 0.8 mmol). Remove the solvent in vacuo to yield 111 mg of the title compound (100%): mass spectrum (ion spray): m/z 640.3 (M+H−HCl).

Workup

  1. customRemove the solvent in vacuo

Sources & evidence

ORD record
ord-97f720396abc42ce9e61e73c3061d5d2
Source dataset
uspto-grants-2009_09
Patent number
US07585977B2

Reaction notes

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