反应详情

Dissolve 4-bromo-2-chloro-1-methylsulfanyl-benzene (4.8 g, 20 mmol) and mCPBA (20 g, 80 mmol) in dichloromethane (100 mL). Stir for 2 hours. Dilute with dichloromethane (300 mL) and water (100 mL). Separate the organic layer and wash with aqueous saturated NaHCO3 (2×100 mL) and brine (100 mL). Dry with MgSO4, filter and concentrate in vacuo. Wash the solid with ether (2×10 mL) and dichloromethane (10 mL) to give 1.7 g of the title compound (31%).

1. customSeparate the organic layer
2. washwash with aqueous saturated NaHCO3 (2×100 mL) and brine (100 mL)
3. dry with materialDry with MgSO4
4. filtrationfilter
5. concentrationconcentrate in vacuo
6. washWash the solid with ether (2×10 mL) and dichloromethane (10 mL)