Hydrochloric Acid → HCID 68519458, compound

HRID 732771Notes

Reaction equation

HRID 732771 reaction equation
[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:41]=[CH:40][C:13]([O:14][C:15]3[C:24]([C:25]4[CH:30]=[CH:29][C:28]([S:31]([CH2:34][C:35]([F:38])([F:37])[F:36])(=[O:33])=[O:32])=[CH:27][CH:26]=4)=[CH:23][CH:22]=[C:21]4[C:16]=3[CH:17]=[CH:18][C:19]([OH:39])=[CH:20]4)=[CH:12][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:42].C(OCC)C>ClCCl>[ClH:42].[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:41]=[CH:40][C:13]([O:14][C:15]3[C:24]([C:25]4[CH:30]=[CH:29][C:28]([S:31]([CH2:34][C:35]([F:36])([F:37])[F:38])(=[O:32])=[O:33])=[CH:27][CH:26]=4)=[CH:23][CH:22]=[C:21]4[C:16]=3[CH:17]=[CH:18][C:19]([OH:39])=[CH:20]4)=[CH:12][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 68518351HCID 68518351, compound

Product 1

HCID 68519458HCID 68519458, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Dissolve the compound of Example 38 (30 mg, 0.051 mmol) in dry dichloromethane (1 mL) and add 2M HCl in diethyl ether (0.10 mL, 0.20 mmol). Stir at room temperature for 1 minute. Remove the solvent by blowing nitrogen over the liquid. Place the residue on a high vacuum pump for 1 hour. Dry the product in a vacuum oven at 45° C. overnight to yield 30 mg of the title compound (97%): mass spectrum (ion spray) m/z=586.3 (M+H−HCl).

Workup

  1. customRemove the solvent
  2. customfor 1 hour
  3. customDry the product in a vacuum oven at 45° C. overnight

Sources & evidence

ORD record
ord-a8c4946fe2344c5da64b41a7fc921d6e
Source dataset
uspto-grants-2009_09
Patent number
US07585977B2

Reaction notes

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