反应详情

温度

52 °C

A crystallisation reactor was charged with 3.0 g cephradine and 50 ml water and heated up to T=52° C. Immediately, the combined filtrates and washings were dosed with constant dosing rate in 60 minutes. The temperature was kept at T=52° C. and the pH at 4.80 by titration with 25% sulfuric acid. Then, the temperature was decreased to 25° C. in 30 minutes. The resulting suspension was filtered through a glass filter. The wetcake was washed with 30 ml water and 2×25 ml 80% acetone (acetone/water=80/20 v/v) and dried. 47.0 g cephradine hydrate, with a water content of 3.4%, was obtained.

1. customwas kept at T=52° C.
2. waitThen, the temperature was decreased to 25° C. in 30 minutes
3. filtrationThe resulting suspension was filtered through a glass
4. filtrationfilter
5. washThe wetcake was washed with 30 ml water and 2×25 ml 80% acetone (acetone/water=80/20 v/v)
6. customdried