Carbonochloridic acid, 4-methoxyphenyl ester → HCID 57838934, compound

HRID 732891Notes

Reaction equation

HRID 732891 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1)=[O:3].[CH2:13]([CH:16]1[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]1)[C:14]#[CH:15]>>[CH2:13]([CH:16]1[CH2:21][CH2:20][N:19]([C:2]([O:4][C:5]2[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=2)=[O:3])[CH2:18][CH2:17]1)[C:14]#[CH:15]

Participants

3

Reactant 2

HCID 82128Carbonochloridic acid, 4-methoxyphenyl esterHCID 18187546Tert-butyl 4-(prop-2-yn-1-yl)piperidine-1-carboxylate

Product 1

HCID 57838934HCID 57838934, compound

Procedure

4-(methoxy)phenyl chloroformate (5.00 g, 26.8 mmol) was added to a solution of tert-butyl 4-(prop-2-ynyl)piperidine-1-carboxylate (4.60 g, 20.9 mmol) according to general procedure 1. Yield=5.02 g, 90%. m/z MH+=274.06. HPLC rt=12.2 min.

Workup

  1. customHPLC rt=12.2 min.

Sources & evidence

ORD record
ord-6bad77878d444749bea8763b9cb0b60a
Source dataset
uspto-grants-2009_09
Patent number
US07589076B2

Reaction notes

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