4-Nitrobenzyl chloroformate → HCID 57838932, compound

HRID 732894Notes

Reaction equation

HRID 732894 reaction equation
Cl[C:2]([O:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1)=[O:3].[CH2:15]([CH:18]1[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]1)[C:16]#[CH:17]>>[CH2:15]([CH:18]1[CH2:23][CH2:22][N:21]([C:2]([O:4][CH2:5][C:6]2[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=2)=[O:3])[CH2:20][CH2:19]1)[C:16]#[CH:17]

Participants

3

Reactant 2

HCID 782054-Nitrobenzyl chloroformateHCID 18187546Tert-butyl 4-(prop-2-yn-1-yl)piperidine-1-carboxylate

Product 1

HCID 57838932HCID 57838932, compound

Procedure

4-(nitro)benzyl chloroformate (5.00 g, 23.2 mmol) was added to a solution of tert-butyl 4-(prop-2-ynyl)piperidine-1-carboxylate (3.98 g, 17.4 mmol) according to general procedure 1. Yield=4.66 g, 86%. m/z MH+=302.98. HPLC rt=12.3 min.

Workup

  1. customHPLC rt=12.3 min.

Sources & evidence

ORD record
ord-d2858376e0854d71abc4c8f5a90e4c73
Source dataset
uspto-grants-2009_09
Patent number
US07589076B2

Reaction notes

Loading…