反应详情

A stirred slurry of toluene-4-sulfonic acid cyanomethyl ester (13.0 g), potassium carbonate (13.0 g) and 2-isopropyl-4-methoxyphenol (9.57 g) in 85 mL of 2-butanone was heated to 55-60 degrees C. for 4 days, then heated to reflux for 18 hours. The resultant slurry was cooled and filtered to remove solids. The filtrate was concentrated under reduced pressure and the residue was redissolved in toluene. The toluene solution was extracted with 1N KOH, and the organic phase was concentrated under reduced pressure to give 20.6 g of a 1:1 (by weight) solution of (2-Isopropyl-4-methoxy-phenoxy)-acetonitrile in toluene, which was used directly in the next step. A aliquot (0.967 g) of this solution was concentrated to dryness to give 0.509 g of crude (2-Isopropyl-4-methoxy-phenoxy)-acetonitrile, MS (M+H)=206.

1. temperatureheated
2. temperatureto reflux for 18 hours
3. temperatureThe resultant slurry was cooled
4. filtrationfiltered
5. customto remove solids
6. concentrationThe filtrate was concentrated under reduced pressure
7. dissolutionthe residue was redissolved in toluene
8. extractionThe toluene solution was extracted with 1N KOH
9. concentrationthe organic phase was concentrated under reduced pressure