Sodium Hydroxide → HCID 9901171, compound

HRID 732972Notes

Reaction equation

HRID 732972 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[C:7]2[N:15]=[N:14][N:13]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-])=O)[CH:18]=3)[C:8]=2[N:9]=[C:10]([NH2:12])[N:11]=1.Cl[Sn]Cl.[OH-].[Na+]>CCO.Cl.O>[NH2:23][C:19]1[CH:18]=[C:17]([CH:22]=[CH:21][CH:20]=1)[CH2:16][N:13]1[C:8]2[N:9]=[C:10]([NH2:12])[N:11]=[C:6]([C:2]3[O:1][CH:5]=[CH:4][CH:3]=3)[C:7]=2[N:15]=[N:14]1

Participants

7

Reactant 3

HCID 14798Sodium HydroxideHCID 24479Stannous ChlorideHCID 9967620HCID 9967620, compound

Product 1

HCID 9901171HCID 9901171, compoundYield 92%

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 7-(2-furyl)-3-(3-nitrobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine (152 mg, 0.45 mmol) in EtOH (2 mL) at 50° C. was treated with a solution of SnCl2 (305 mg, 1.35 mmol) in conc. HCl (0.7 mL), stirred for 2 h, cooled, diluted with water, basified to pH 10 (5-M, NaOH) and filtered to give the title compound (127 mg, 92%) as a white solid.

Workup

  1. temperaturecooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-9767d352262d4d2481ab0db8c7cc81b4
Source dataset
uspto-grants-2009_09
Patent number
US07589097B2

Reaction notes

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