Sodium Hydroxide → HCID 9813851, compound

HRID 732983Notes

Reaction equation

HRID 732983 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([C:17]2[O:18][CH:19]=[CH:20][CH:21]=2)[C:5]2[N:10]=[N:9][N:8]([CH2:11][C:12]([O:14]CC)=[O:13])[C:6]=2[N:7]=1.[OH-].[Na+].B(Br)(Br)Br>CO>[NH2:1][C:2]1[N:3]=[C:4]([C:17]2[O:18][CH:19]=[CH:20][CH:21]=2)[C:5]2[N:10]=[N:9][N:8]([CH2:11][C:12]([OH:14])=[O:13])[C:6]=2[N:7]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 25134Boron tribromideHCID 9921985Ethyl 5-Amino-7-(2-Furyl)-3H-[1,2,3]Triazolo[4,5-D]Pyrimidin-3-Ylacetate

Product 1

HCID 9813851HCID 9813851, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of ethyl 5-amino-7-(2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-ylacetate (547 mg, 1.89 mmol) in MeOH (5 mL) was treated with aqueous NaOH (2 mL, 2-M, 4 mmol), refluxed for 10 min, cooled, acidified with aqueous HCl (1-M), filtered and dried to give the title compound (417 mg, 85%) as a white solid.

Workup

  1. temperaturerefluxed for 10 min
  2. temperaturecooled
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-ae682b777df547e3beba023d3e9e2b89
Source dataset
uspto-grants-2009_09
Patent number
US07589097B2

Reaction notes

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