Hydrochloric Acid → HCID 178479116, compound

HRID 733002Notes

Reaction equation

HRID 733002 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:31]=[CH:32][CH:33]=1)[CH2:7][N:8]1[C:12]2[N:13]=[C:14]([NH2:30])[N:15]=[C:16]([C:17]3[N:21](COCC[Si](C)(C)C)[N:20]=[CH:19][CH:18]=3)[C:11]=2[N:10]=[N:9]1)([O-:3])=[O:2].[ClH:34]>CO.O1CCOCC1>[ClH:34].[N+:1]([C:4]1[CH:5]=[C:6]([CH:31]=[CH:32][CH:33]=1)[CH2:7][N:8]1[C:12]2[N:13]=[C:14]([NH2:30])[N:15]=[C:16]([C:17]3[CH:18]=[CH:19][NH:20][N:21]=3)[C:11]=2[N:10]=[N:9]1)([O-:3])=[O:2]

Participants

5

Reactant 2

HCID 313Hydrochloric Acid2×HCID 21874781HCID 21874781, compound

Product 1

HCID 178479116HCID 178479116, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 3-(3-nitrobenzyl)-7-(1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrazol-5-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine (156 mg, 0.34 mmol) in MeOH (2 mL) was treated with 4-M HCl in dioxane (4 mL) stirred at room temperature for 2 h, concentrated in vacuo, triturated with Et2O and filtered to give the title compound (110 mg, 97%) as a yellow solid.

Workup

  1. concentrationconcentrated in vacuo
  2. customtriturated with Et2O
  3. filtrationfiltered

Sources & evidence

ORD record
ord-943062ae2a1b42dea38145171f4fb6b4
Source dataset
uspto-grants-2009_09
Patent number
US07589097B2

Reaction notes

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