反应详情

A stirred solution of 2-[(phenylsulfonyl)methyl]aniline (247 mg, 1.00 mmol) in 4N HCl (50 ml) is treated with a solution of NaNO2 (100 mg, 1.5 mmol) in water at ice-bath temperatures, stirred for 30 min., neutralized with 10% NaOH and filtered. The filtercake is dissolved in CH2Cl2, dried over MgSO4 and concentrated in vacuo to afford the title product as a tan solid, 240 mg (93% yield), mp 118° C., identified by mass spectral and HNMR analyses.

1. filtrationfiltered
2. dissolutionThe filtercake is dissolved in CH2Cl2
3. dry with materialdried over MgSO4
4. concentrationconcentrated in vacuo