反应详情

The crude product of the corresponding [(1,4-dioxaspiro[4.5]dec-8-yl)-methyl]-dimethylamine (88 mmol) was dissolved in water (40 ml), combined with conc. hydrochloric acid (59 ml) and stirred for 20 h at RT. The reaction mixture was extracted with diethyl ether (2×100 ml), the aqueous phase was alkalized with 5N NaOH with ice cooling, extracted with dichloromethane (3×100 ml), dried and evaporated. The products were obtained as white solids or oils.

1. extractionThe reaction mixture was extracted with diethyl ether (2×100 ml)
2. extractionextracted with dichloromethane (3×100 ml)
3. customdried
4. customevaporated
5. customThe products were obtained as white solids or oils