HCID 68584487, compound → HCID 67232107, compound

HRID 733091Notes

Reaction equation

HRID 733091 reaction equation
C(OC([NH:8][CH2:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2([C:20]([O:22]C(C)(C)C)=[O:21])[CH2:19][CH2:18]2)[CH2:12][CH2:11]1)=O)(C)(C)C>Cl.O1CCOCC1>[NH2:8][CH2:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2([C:20]([OH:22])=[O:21])[CH2:19][CH2:18]2)[CH2:12][CH2:11]1

Participants

4

Reactant 1

HCID 68584487HCID 68584487, compound

Product 1

HCID 67232107HCID 67232107, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 1-[(4-{[(tert-butoxycarbonyl)amino]methyl}piperidin-1-yl)methyl]cyclopropanecarboxylate (211 mg, 0.57 mmol, step 2 of Example 3) was dissolved in 10% HCl in dioxane (5 mL) and the mixture was stirred for 4 h at room temperature. Resultant brown suspension was concentrated to give 150 mg (quant.) of the title compound as a pale brown solid. This was used without further purification.

Workup

  1. concentrationResultant brown suspension was concentrated

Sources & evidence

ORD record
ord-428ea113d8ef437d8dbff5812a0493b2
Source dataset
uspto-grants-2009_09
Patent number
US07589109B2

Reaction notes

Loading…