反应详情

To a stirred solution of tert-butyl(piperidin-4-ylmethyl)carbamate (7.0 g, 33 mmol) in ethanol (19 mL), paraformaldehyde (1.2 g, 39 mmol) and K2CO3 (5.4 g, 39 mmol) were added at ambient temperature. The mixture was stirred at ambident temperature for 4 h. The mixture was filtered and the filter cake was washed with ethanol (50 mL). The volatile components were removed by evaporation to give 8.9 g (quant.) of the title compound as a white powder.

1. filtrationThe mixture was filtered
2. washthe filter cake was washed with ethanol (50 mL)
3. customThe volatile components were removed by evaporation