Ethyl Acrylate → HCID 67232240, compound

HRID 733099Notes

Reaction equation

HRID 733099 reaction equation
[C:1]([O:5][C:6](=[O:15])[NH:7][CH2:8][CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1)([CH3:4])([CH3:3])[CH3:2].[C:16]([O:20][CH2:21][CH3:22])(=[O:19])[CH:17]=[CH2:18]>C(O)C>[C:1]([O:5][C:6]([NH:7][CH2:8][CH:9]1[CH2:10][CH2:11][N:12]([CH2:18][CH2:17][C:16]([O:20][CH2:21][CH3:22])=[O:19])[CH2:13][CH2:14]1)=[O:15])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 8821Ethyl AcrylateHCID 723429Tert-butyl (piperidin-4-ylmethyl)carbamate

Product 1

HCID 67232240HCID 67232240, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of tert-butyl(piperidin-4-ylmethyl)carbamate (3.0 g, 14 mmol) and ethyl acrylate (1.7 g, 17 mmol) in ethanol (30 mL) was refluxed for 1 h. After cooled to room temperature, the solution was concentrated to give clear colorless oil. The residue was chromatographed on a silica gel column eluting with CH2Cl2/methanol (14:1) to give 4.0 g (91%) of the title compound as clear colorless oil.

Workup

  1. temperaturewas refluxed for 1 h
  2. concentrationthe solution was concentrated
  3. customto give clear colorless oil
  4. customThe residue was chromatographed on a silica gel column
  5. washeluting with CH2Cl2/methanol (14:1)

Sources & evidence

ORD record
ord-364c885dd93e46e8aef8fb8a635da7e6
Source dataset
uspto-grants-2009_09
Patent number
US07589109B2

Reaction notes

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