2-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → Ethyl-5-methyl-1-[2'-(trifluoromethoxy)-1,1'-biphenyl-3-yl]-1H-pyrazole-3-carboxylate
Reaction equation
Br[C:2]1[CH:3]=[C:4]([N:8]2[C:12]([CH3:13])=[CH:11][C:10]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[F:19][C:20]([F:32])([F:31])[O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1B(O)O>>[CH2:17]([O:16][C:14]([C:10]1[CH:11]=[C:12]([CH3:13])[N:8]([C:4]2[CH:3]=[C:2]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[O:21][C:20]([F:19])([F:32])[F:31])[CH:7]=[CH:6][CH:5]=2)[N:9]=1)=[O:15])[CH3:18]Participants
3
Procedure
The titled compound was prepared by reacting ethyl 1-(3-bromophenyl)-5-methyl-1H-pyrazole-3-carboxylate (from Step 1 of EXAMPLE 1) with 2-(Trifluoromethoxy)phenylboronic acid (from Step 3 of EXAMPLE 1) under the reaction condition described in Step 4 of EXAMPLE 1.
Sources & evidence
- ORD record
- ord-42d9341cdd6d427aad641ffc9503895f
- Source dataset
- uspto-grants-2009_09
- Patent number
- US07589116B2
Reaction notes
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