Isoamyl Nitrite → HCID 53419315, compound

HRID 733135Notes

Reaction equation

HRID 733135 reaction equation
N[C:2]1[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][N:4]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Br:18])[CH:13]=2)[N:3]=1.C(ON=O)CC(C)C>C1COCC1>[CH2:10]([O:9][C:7]([C:6]1[CH:2]=[N:3][N:4]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Br:18])[CH:13]=2)[CH:5]=1)=[O:8])[CH3:11]

Participants

4

Reactant 2

HCID 8053Isoamyl NitriteHCID 57428254HCID 57428254, compound

Product 1

HCID 53419315HCID 53419315, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of the ester from Step 1 (0.5 g, 1.61 mmol) in THF (4.3 mL) was added isoamylnitrite (0.434 mL, 3.23 mmol), and the mixture was refluxed for 16 hours. It was cooled to room temperature, concentrated, dried and used as such for the subsequent step without any purification.

Workup

  1. temperaturethe mixture was refluxed for 16 hours
  2. concentrationconcentrated
  3. customdried
  4. customwithout any purification

Sources & evidence

ORD record
ord-37887dfd4d7249bfaa4acf1cd72e031b
Source dataset
uspto-grants-2009_09
Patent number
US07589116B2

Reaction notes

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