Isopropylamine → HCID 57839525, compound

HRID 733151Notes

Reaction equation

HRID 733151 reaction equation
F[B-](F)(F)F.[N:6]1(OC(N(C)C)=[N+](C)C)[C:10]2[CH:11]=CC=C[C:9]=2N=N1.C(N(C(C)C)C(C)C)C.[Cl:32][C:33]1[CH:34]=[C:35]([N:40]2[C:44]3=[N:45][CH:46]=[C:47]([S:48]([N:51]4[CH2:54][CH2:53][C@H:52]4[C:55](O)=[O:56])(=[O:50])=[O:49])[N:43]3[C@:42]([CH3:71])([CH2:58][C:59]3[CH:64]=[CH:63][C:62]([C:65]4[CH:66]=[N:67][CH:68]=[N:69][CH:70]=4)=[CH:61][CH:60]=3)[C:41]2=[O:72])[CH:36]=[C:37]([Cl:39])[CH:38]=1.C(N)(C)C.[NH4+].[Cl-]>C(Cl)Cl>[CH:10]([NH:6][C:55]([C@@H:52]1[CH2:53][CH2:54][N:51]1[S:48]([C:47]1[N:43]2[C@:42]([CH3:71])([CH2:58][C:59]3[CH:64]=[CH:63][C:62]([C:65]4[CH:70]=[N:69][CH:68]=[N:67][CH:66]=4)=[CH:61][CH:60]=3)[C:41](=[O:72])[N:40]([C:35]3[CH:34]=[C:33]([Cl:32])[CH:38]=[C:37]([Cl:39])[CH:36]=3)[C:44]2=[N:45][CH:46]=1)(=[O:50])=[O:49])=[O:56])([CH3:11])[CH3:9]

Participants

7

Reactant 5

HCID 6363IsopropylamineHCID 25517Ammonium ChlorideHCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 11842674HCID 11842674, compound

Product 1

HCID 57839525HCID 57839525, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

O-Benzotriazol-1-yl-N,N,N′,N′,-tetramethyluronium tetrafluoroborate (0.016 g), (i-Pr)2EtN (0.013 mL) and (S)-1-[(R)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-5-(4-pyrimidin-5-yl-benzyl)-6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonyl]-azetidine-2-carboxylic acid (0.023 g, 0.04 mmol) were combined in CH2Cl2 (2 mL) at room temperature. Isopropyl amine (0.0064 mL) was then added and the reaction was stirred for 18 h. The reaction was diluted with CH2Cl2 and poured into saturated aqueous NH4Cl.

Sources & evidence

ORD record
ord-7286a649153f4e6c83e5e8444fb19e60
Source dataset
uspto-grants-2009_09
Patent number
US07589114B2

Reaction notes

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