反应详情

25.0 g of 4-trifluoromethyl-phthalic acid were dissolved in 50 ml of HOAc and 15.1 ml of acetic anhydride added. The mixture was refluxed for 6 h. The solvent was then removed in vacuo. The residue was treated three times with 50 ml of toluene each followed by the removal of the solvent in vacuo. Yield 23.1 g of a colorless oil (Rf(CH2Cl2)=0.60).

1. temperatureThe mixture was refluxed for 6 h
2. customThe solvent was then removed in vacuo
3. additionThe residue was treated three times with 50 ml of toluene
4. customeach followed by the removal of the solvent in vacuo