HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 5-(Trifluoromethyl)isobenzofuran-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 4-(Trifluoromethyl)phthalic acid | HCID 599039 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-(Trifluoromethyl)isobenzofuran-1,3-dione | HCID 12717789 | — |
Reaction Steps
25.0 g of 4-trifluoromethyl-phthalic acid were dissolved in 50 ml of HOAc and 15.1 ml of acetic anhydride added. The mixture was refluxed for 6 h. The solvent was then removed in vacuo. The residue was treated three times with 50 ml of toluene each followed by the removal of the solvent in vacuo. Yield 23.1 g of a colorless oil (Rf(CH2Cl2)=0.60).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07589117B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-dba24d8a2a644929bcb024ae3e0cc8e6 |
| Source note | uspto-grants-2009_09 |