反应详情

To a solution of methyl 2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoate (obtained in example 1) (0.72 g, 2.40 mmol) in MeOH (9.7 mL), KOH (0.51 g, 86%; 7.80 mmol) dissolved in H2O (3 mL) was added and the resulting mixture was refluxed for 4 hours. The mixture was allowed to cool and MeOH was evaporated. The residue thus obtained was treated with H2O (5 mL) and the resulting solution was acidified with 6 N HCl. The white solid formed was collected by filtration, washed with cold H2O and dried in vacuo, yielding the title compound (55% yield).

1. additionwas added
2. temperaturethe resulting mixture was refluxed for 4 hours
3. temperatureto cool
4. customMeOH was evaporated
5. customThe residue thus obtained
6. customThe white solid formed
7. filtrationwas collected by filtration
8. washwashed with cold H2O
9. customdried in vacuo