Methylamine → HCID 10398120, compound

HRID 733308Notes

Reaction equation

CN.[C:3]([C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([NH:16][CH3:17])=O)=[C:9]([O:18]C)[CH:8]=1)([CH3:6])([CH3:5])[CH3:4]>>[C:3]([C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][NH:16][CH3:17])=[C:9]([OH:18])[CH:8]=1)([CH3:6])([CH3:4])[CH3:5]

Participants

Reactant 2

HCID 6329Methylamine

HCID 68717884HCID 68717884, compound

Product 1

HCID 10398120HCID 10398120, compound

Procedure

Reaction of the product of Step B in Example 75 with methylamine instead of dimethylamine as described in Step C of Example 75 afforded 2-(4-tert-butyl-2-methoxyphenyl)-N-methylacetamide. Treatment of this later product according to the procedures described in Steps D and E of example 75 affords the title compound.

Sources & evidence

ORD record: ord-4c72d0e46dc04a7280eda94b15116881
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07589127B2

Reaction notes

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