HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-Pyrrolidine-2-carboxylic acid ((S)-2-hydroxy-propyl)-amide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- | HCID 85083 | — |
| Reactant | (S)-(+)-1-Aminopropan-2-ol | HCID 7311736 | — |
| Reactant | Edc hobt | HCID 86583742 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (S)-Pyrrolidine-2-carboxylic acid ((S)-2-hydroxy-propyl)-amide hydrochloride | HCID 86603946 | — |
Reaction Steps
Compound I6 was prepared by EDC/HOBT-coupling of (S)-2-hydroxy-propylamine with pyrrolidine-1,2(S)-dicarboxylic acid 1-t-butyl ester (analogous to Step A of Example I4), followed by HCl-cleavage in dioxane (Step B of Example I5). The crude salt was used as such.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07589091B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-d4447fc29801430397f557b00066ea83 |
| Source note | uspto-grants-2009_09 |