HCID 10288897, compound → HCID 10237550, compound

HRID 733322Notes

Reaction equation

HRID 733322 reaction equation
[CH3:1][NH:2][C:3]([C@@H:5]1[CH2:10][CH2:9][CH2:8][CH2:7][N:6]1[C:11](=[O:35])[C@H:12]([C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=1)[C@@H:13]([C:23](=[O:26])[NH:24][OH:25])[CH2:14][O:15]CC1C=CC=CC=1)=[O:4]>CO.[Pd]>[CH3:1][NH:2][C:3]([C@@H:5]1[CH2:10][CH2:9][CH2:8][CH2:7][N:6]1[C:11](=[O:35])[C@H:12]([C:27]1[CH:28]=[CH:29][C:30]([O:33][CH3:34])=[CH:31][CH:32]=1)[C@@H:13]([C:23](=[O:26])[NH:24][OH:25])[CH2:14][OH:15])=[O:4]

Participants

4

Reactant 1

HCID 10288897HCID 10288897, compound

Product 1

HCID 10237550HCID 10237550, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of hydroxamic acid 7 (100 mg, 0.21 mmol) in 20 ml of methanol was hydrogenated under normal pressure with 50 mg of palladium on barium sulfate for about 5 hours. After filtration of the catalyst the solvent was evaporated and the crude product was purified by preparative HPLC to give a white solid. Yield: 53 mg (65%).

Workup

  1. filtrationAfter filtration of the catalyst the solvent
  2. customwas evaporated
  3. customthe crude product was purified by preparative HPLC
  4. customto give a white solid

Sources & evidence

ORD record
ord-e6fb92a8e4344daeb4c4c309312235bd
Source dataset
uspto-grants-2009_09
Patent number
US07589091B2

Reaction notes

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