反应详情

To a stirred solution of 154 g of ethyl [4-[2-(5-cyano-2-hydroxybenzenesulfonylamino)ethyl]-2′-methanesulfonyl-biphenyl-3-yloxy]acetate in 1.23 L of ethanol was added 275 mL of 2 mol/L sodium hydroxide solution under ice-cooling, and the mixture was stirred under ice-cooling for 1.5 hours. To the reaction mixture was added dropwise 275 mL of 2 mol/L hydrochloric acid, and ethanol was removed under reduced pressure. The residue was extracted with ethyl acetate, and the organic layer was washed with brine. The solvent was dried over anhydrous magnesium sulfate, and removed under reduced pressure to give 149 g of [4-[2-(5-cyano-2-hydroxybenzenesulfonylamino)-ethyl]-2′-methanesulfonylbiphenyl-3-yloxy]acetic acid.

1. temperaturecooling
2. temperaturecooling for 1.5 hours
3. customwas removed under reduced pressure
4. extractionThe residue was extracted with ethyl acetate
5. washthe organic layer was washed with brine
6. dry with materialThe solvent was dried over anhydrous magnesium sulfate
7. customremoved under reduced pressure