反应详情

A 50 ml reactor is charged with 0.165 g (1.02 mmol) of 1H-indazole-3-carboxylic acid and 1 ml of thionyl chloride and the mixture is heated at ref lux for 1 h 30 min and concentrated under reduced pressure. Then 1.2 ml of pyridine and 0.30 g (2.67 mmol) of 1,4-diazabicyclo[3.2.1]octane are added and the mixture is heated at reflux for 1 h 30 min.

1. temperaturethe mixture is heated at ref lux for 1 h 30 min
2. concentrationconcentrated under reduced pressure
3. temperaturethe mixture is heated
4. temperatureat reflux for 1 h 30 min.