Thionyl Chloride → 3-(1,4-Diazabicyclo[3.2.1]oct-4-ylcarbonyl)-1H-indazole hydrochloride

Participants

Reaction Steps

A 50 ml reactor is charged with 0.165 g (1.02 mmol) of 1H-indazole-3-carboxylic acid and 1 ml of thionyl chloride and the mixture is heated at ref lux for 1 h 30 min and concentrated under reduced pressure. Then 1.2 ml of pyridine and 0.30 g (2.67 mmol) of 1,4-diazabicyclo[3.2.1]octane are added and the mixture is heated at reflux for 1 h 30 min.

Provenance & Evidence