HCID 11539108, compound → HCID 69079770, compound

HRID 733394Notes

Reaction equation

HRID 733394 reaction equation
[CH:1]12NC(CC1)CC(C1C3C=CC(C4C=CC=CC=4NC(=O)C)=CC=3OC3C1=CC=CC=3)C2.N1C=CC=C(C2C=CC3C(C4CC5NC(CC5)C4)C4C(OC=3C=2)=CC=CC=4)C=1.[O:61]1[CH:65]=[CH:64]C=[C:62]1[CH2:66][N:67]1[CH:72]2[CH2:73][CH2:74][CH:68]1[CH2:69][CH:70]([CH:75]1[C:88]3[CH:87]=[CH:86][C:85]([C:89]4[CH:94]=[CH:93][CH:92]=[CH:91][C:90]=4[NH:95][C:96](=[O:98])[CH3:97])=[CH:84][C:83]=3[O:82][C:81]3[C:76]1=[CH:77][CH:78]=[CH:79][CH:80]=3)[CH2:71]2>>[O:61]1[CH:65]=[CH:64][C:66]([N:67]2[CH:68]3[CH2:74][CH2:73][C:72]2([CH3:1])[CH2:71][CH:70]([CH:75]2[C:88]4[CH:87]=[CH:86][C:85]([C:89]5[CH:94]=[CH:93][CH:92]=[CH:91][C:90]=5[NH:95][C:96](=[O:98])[CH3:97])=[CH:84][C:83]=4[O:82][C:81]4[C:76]2=[CH:77][CH:78]=[CH:79][CH:80]=4)[CH2:69]3)=[CH:62]1

Participants

4

Reactant 3

HCID 11539108HCID 11539108, compoundHCID 57839257HCID 57839257, compound2×HCID 69076892HCID 69076892, compound

Product 1

HCID 69079770HCID 69079770, compound

Procedure

Using an adaptation of the method described in Procedure 12, substituting N-{2-[9-(8-aza-bicyclo[3.2.1]oct-3-yl)-9H-xanthen-3-yl]-phenyl}-acetamide, 7b for 3-(3-pyridin-3-yl-9H-xanthen-9-yl)-8-aza-bicyclo[3.2.1]octane, 3b, title compound N-{2-[9-(8-furan-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-9H-xanthen-3-yl]-phenyl}-acetamide, 13b was obtained as a TFA salt. MS m/z (MH+) 505.2.

Sources & evidence

ORD record
ord-ab3b07205f8d452a9f23e0abcaa560d2
Source dataset
uspto-grants-2009_09
Patent number
US07589104B2

Reaction notes

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