9-[8-(2,2,2-Trifluoroacetyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-9H-xanthene-3-carbonitrile → 9-(8-Aza-bicyclo[3.2.1]oct-3-yl)-9H-xanthene-3-carbonitrile

HRID 733420Notes

Reaction equation

HRID 733420 reaction equation
FC(F)(F)C([N:5]1[CH:10]2[CH2:11][CH2:12][CH:6]1[CH2:7][CH:8]([CH:13]1[C:26]3[CH:25]=[CH:24][C:23]([C:27]#[N:28])=[CH:22][C:21]=3[O:20][C:19]3[C:14]1=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:9]2)=O.FC(F)(F)C(N1C2CCC1CC(C1C3C=CC(C4NN=NN=4)=CC=3OC3C1=CC=CC=3)C2)=O>>[CH:10]12[NH:5][CH:6]([CH2:12][CH2:11]1)[CH2:7][CH:8]([CH:13]1[C:26]3[CH:25]=[CH:24][C:23]([C:27]#[N:28])=[CH:22][C:21]=3[O:20][C:19]3[C:14]1=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:9]2

Participants

3

Reactant 2

HCID 578392559-[8-(2,2,2-Trifluoroacetyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-9H-xanthene-3-carbonitrileHCID 178521660HCID 178521660, compound2×

Product 1

HCID 578392709-(8-Aza-bicyclo[3.2.1]oct-3-yl)-9H-xanthene-3-carbonitrile

Procedure

Using an adaptation of the method described in Procedure 23, substituting 9-[8-(2,2,2-trifluoroacetyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-9H-xanthene-3-carbonitrile, 3j for 2,2,2-trifluoro-1-{3-[3-(1H-tetrazol-5-yl)-9H-xanthen-9-yl]-8-aza-bicyclo-[3.2.1]oct-8-yl}-ethanone, 4j, the title compound 9-(8-aza-bicyclo[3.2.1]oct-3-yl)-9H-xanthene-3-carbonitrile, 1m was obtained.

Sources & evidence

ORD record
ord-99a357edefa746c090d172e60f886f82
Source dataset
uspto-grants-2009_09
Patent number
US07589104B2

Reaction notes

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