Hydrogen Bromide → HCID 16085805, compound

HRID 733428Notes

Reaction equation

HRID 733428 reaction equation
[BrH:1].[CH2:2]([O:4][C:5]1[CH:6]=[C:7]([C:13]#[CH:14])[CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[CH3:3]>>[Br:1][C:13]([C:7]1[CH:8]=[CH:9][C:10]([O:11][CH3:12])=[C:5]([O:4][CH2:2][CH3:3])[CH:6]=1)=[CH2:14]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 16085804HCID 16085804, compound

Product 1

HCID 16085805HCID 16085805, compoundYield 93.3%

Procedure

According to the General Procedure D, HBr (33% in acetic acid, 1.22 ml, 0.51 g, 6.25 mmol) and 3-Ethoxy-4-methoxyphenylacetylene (1.10 g, 6.25 mmol) are converted to give after workup and chromatography (SiO2 PE/EE 5:1, Rf=0.35) the title compound (1.53 g, 5.83 mmol) as a brown oil; C11H13BrO2 (257.13).

Sources & evidence

ORD record
ord-a5b79fff4ee042a18448060f543839a9
Source dataset
uspto-grants-2009_09
Patent number
US07589205B2

Reaction notes

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