反应详情

To a solution of methyl {4-[(hydroxyimino)methyl]phenoxy}acetate (30 g, 0.14 mol) in methanol (650 mL) was added glacial acetic acid (6.8 g) and passed N2 for 30 min. To this was added Pd/C (10%, 3 g) and hydrogenated under 2 bars of pressure for 12 h. The reaction mixture was concentrated under vacuum. The crude product was treated with EtOAc (500 mL) and the white product filtered off The solid was dried under vacuum to give the title compound (29 g, 81%).

1. customfor 30 min
2. concentrationThe reaction mixture was concentrated under vacuum
3. additionThe crude product was treated with EtOAc (500 mL)
4. filtrationthe white product filtered off The solid
5. customwas dried under vacuum