Acetyl chloride → ethyl (2E)-3-{4-[acetyl(4-dec-1-ynylbenzyl)amino]phenyl}acrylate

HRID 733538Notes

Reaction equation

HRID 733538 reaction equation
[C:1]([C:11]1[CH:31]=[CH:30][C:14]([CH2:15][NH:16][C:17]2[CH:22]=[CH:21][C:20](/[CH:23]=[CH:24]/[C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:19][CH:18]=2)=[CH:13][CH:12]=1)#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[C:32](Cl)(=[O:34])[CH3:33]>>[C:32]([N:16]([CH2:15][C:14]1[CH:30]=[CH:31][C:11]([C:1]#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])=[CH:12][CH:13]=1)[C:17]1[CH:18]=[CH:19][C:20](/[CH:23]=[CH:24]/[C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:21][CH:22]=1)(=[O:34])[CH3:33]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 11200896ethyl (2E)-3-{4-[(4-dec-1-ynylbenzyl)amino)phenyl}acrylate

Product 1

HCID 57841323ethyl (2E)-3-{4-[acetyl(4-dec-1-ynylbenzyl)amino]phenyl}acrylate

Procedure

The title compound was prepared following the procedure E using ethyl (2E)-3-{4-[(4-dec-1-ynylbenzyl)amino]phenyl}acrylate and acetyl chloride as a yellow oil (97%). M+ (ESI): 460.2. HPLC, Rt: 6.0 min (purity: 98.8%).

Sources & evidence

ORD record
ord-38fc05c73458452790ffcbbd6b4b4411
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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