Benzyloxyacetyl chloride → HCID 57841363, compound

HRID 733557Notes

Reaction equation

Cl.[CH2:2]([C:6]1[CH:11]=[CH:10][C:9]([C:12]#[C:13][C:14]2[CH:34]=[CH:33][C:17]([CH2:18][NH:19][C:20]3[CH:32]=[CH:31][C:23]4[O:24][C:25]([CH3:30])([CH3:29])[O:26][C:27](=[O:28])[C:22]=4[CH:21]=3)=[CH:16][CH:15]=2)=[CH:8][CH:7]=1)[CH2:3][CH2:4][CH3:5].[CH2:35]([O:42][CH2:43][C:44](Cl)=[O:45])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[CH2:35]([O:42][CH2:43][C:44]([N:19]([CH2:18][C:17]1[CH:33]=[CH:34][C:14]([C:13]#[C:12][C:9]2[CH:8]=[CH:7][C:6]([CH2:2][CH2:3][CH2:4][CH3:5])=[CH:11][CH:10]=2)=[CH:15][CH:16]=1)[C:20]1[CH:32]=[CH:31][C:23]2[O:24][C:25]([CH3:30])([CH3:29])[O:26][C:27](=[O:28])[C:22]=2[CH:21]=1)=[O:45])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1

Participants

Reactant 2

HCID 177085Benzyloxyacetyl chloride

HCID 68419698HCID 68419698, compound

Product 1

HCID 57841363HCID 57841363, compound

Procedure

The titled compound was prepared following the procedure K using 6-({4-[(4-butylphenyl)ethynyl]benzyl}amino)-2,2-dimethyl-4H-1,3-benzodioxin-4-one hydrochloride and (benzyloxy)acetyl chloride as a yellow oil (88%). M+ (ESI): 588.5. HPLC, Rt: 5.76 min (Purity: 100%).

Sources & evidence

ORD record: ord-4ea38703be404b14a47118f87258d778
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07589232B2

Reaction notes

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