Benzo[b]thiophene-2-carbonyl Chloride → HCID 57841380, compound

HRID 733563Notes

Reaction equation

HRID 733563 reaction equation
Cl.[CH2:2]([C:6]1[CH:11]=[CH:10][C:9]([C:12]#[C:13][C:14]2[CH:34]=[CH:33][C:17]([CH2:18][NH:19][C:20]3[CH:32]=[CH:31][C:23]4[O:24][C:25]([CH3:30])([CH3:29])[O:26][C:27](=[O:28])[C:22]=4[CH:21]=3)=[CH:16][CH:15]=2)=[CH:8][CH:7]=1)[CH2:3][CH2:4][CH3:5].[S:35]1[C:39]2[CH:40]=[CH:41][CH:42]=[CH:43][C:38]=2[CH:37]=[C:36]1[C:44](Cl)=[O:45]>>[CH2:2]([C:6]1[CH:7]=[CH:8][C:9]([C:12]#[C:13][C:14]2[CH:34]=[CH:33][C:17]([CH2:18][N:19]([C:20]3[CH:32]=[CH:31][C:23]4[O:24][C:25]([CH3:30])([CH3:29])[O:26][C:27](=[O:28])[C:22]=4[CH:21]=3)[C:44]([C:36]3[S:35][C:39]4[CH:40]=[CH:41][CH:42]=[CH:43][C:38]=4[CH:37]=3)=[O:45])=[CH:16][CH:15]=2)=[CH:10][CH:11]=1)[CH2:3][CH2:4][CH3:5]

Participants

3

Reactant 2

HCID 142384Benzo[b]thiophene-2-carbonyl ChlorideHCID 68419698HCID 68419698, compound

Product 1

HCID 57841380HCID 57841380, compound

Procedure

The titled compound was prepared following the procedure K using 6-({4-[(4-butylphenyl)ethynyl]benzyl}amino)-2,2-dimethyl-4H-1,3-benzodioxin-4-one hydrochloride and 1-benzothiophene-2-carbonyl chloride as a yellow oil (95%). HPLC, Rt: 6.04 min (Purity: 92.1%).

Sources & evidence

ORD record
ord-21cfae537ca0420f8c6bdca3c85f57d1
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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