Isoxazole-5-carbonyl chloride → HCID 57841414, compound

HRID 733608Notes

Reaction equation

HRID 733608 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:30]=[CH:29][C:13]([CH2:14][NH:15][C:16]3[CH:28]=[CH:27][C:19]4[O:20][C:21]([CH3:26])([CH3:25])[O:22][C:23](=[O:24])[C:18]=4[CH:17]=3)=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[O:31]1[C:35]([C:36](Cl)=[O:37])=[CH:34][CH:33]=[N:32]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]#[C:9][C:10]2[CH:30]=[CH:29][C:13]([CH2:14][N:15]([C:16]3[CH:28]=[CH:27][C:19]4[O:20][C:21]([CH3:26])([CH3:25])[O:22][C:23](=[O:24])[C:18]=4[CH:17]=3)[C:36]([C:35]3[O:31][N:32]=[CH:33][CH:34]=3)=[O:37])=[CH:12][CH:11]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 2736707Isoxazole-5-carbonyl chlorideHCID 111543016-({4-[(4-chlorophenyl)ethynyl]benzyl}amino)-2,2-dimethyl-4H-1,3-benzodioxin-4-one

Product 1

HCID 57841414HCID 57841414, compound

Procedure

The titled compound was prepared following the procedure E using 6-({4-[(4-chlorophenyl)ethynyl]benzyl}amino)-2,2-dimethyl-4H-1,3-benzodioxin-4-one and isoxazole-5-carbonyl chloride as a yellow oil (72%). M− (ESI): 511.5; M+ (ESI): 513.1. HPLC, Rt: 5.38 min (Purity: 99.1%).

Sources & evidence

ORD record
ord-fcf5415550f34884ab70a8685f5c2d35
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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