Sodium Hydroxide → HCID 11397323, compound

HRID 733609Notes

Reaction equation

HRID 733609 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:37]=[CH:36][C:13]([CH2:14][N:15]([C:23]3[CH:35]=[CH:34][C:26]4[O:27]C(C)(C)[O:29][C:30](=[O:31])[C:25]=4[CH:24]=3)[C:16]([C:18]3[O:22][N:21]=[CH:20][CH:19]=3)=[O:17])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]#[C:9][C:10]2[CH:11]=[CH:12][C:13]([CH2:14][N:15]([C:16]([C:18]3[O:22][N:21]=[CH:20][CH:19]=3)=[O:17])[C:23]3[CH:35]=[CH:34][C:26]([OH:27])=[C:25]([CH:24]=3)[C:30]([OH:31])=[O:29])=[CH:36][CH:37]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 57841414HCID 57841414, compound

Product 1

HCID 11397323HCID 11397323, compound

Procedure

The titled compound was prepared following the procedure C using N-{4-[(4-chlorophenyl)ethynyl]benzyl}-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-6-yl)isoxazole-5-carboxamide and NaOH as a yellow solid (55%). M− (ESI): 470.7; M+ (ESI): 472.6. HPLC, Rt: 4.56 min (Purity: 71.3%).

Sources & evidence

ORD record
ord-0a75c3de3a8a4eb2bb06ab7d8c663641
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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