3-Fluorobenzoyl chloride → HCID 57841336, compound

HRID 733616Notes

Reaction equation

HRID 733616 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:30]=[CH:29][C:13]([CH2:14][NH:15][C:16]3[CH:28]=[CH:27][C:19]4[O:20][C:21]([CH3:26])([CH3:25])[O:22][C:23](=[O:24])[C:18]=4[CH:17]=3)=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[F:31][C:32]1[CH:33]=[C:34]([CH:38]=[CH:39][CH:40]=1)[C:35](Cl)=[O:36]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]#[C:9][C:10]2[CH:30]=[CH:29][C:13]([CH2:14][N:15]([C:16]3[CH:28]=[CH:27][C:19]4[O:20][C:21]([CH3:26])([CH3:25])[O:22][C:23](=[O:24])[C:18]=4[CH:17]=3)[C:35](=[O:36])[C:34]3[CH:38]=[CH:39][CH:40]=[C:32]([F:31])[CH:33]=3)=[CH:12][CH:11]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 743763-Fluorobenzoyl chlorideHCID 111543016-({4-[(4-chlorophenyl)ethynyl]benzyl}amino)-2,2-dimethyl-4H-1,3-benzodioxin-4-one

Product 1

HCID 57841336HCID 57841336, compound

Procedure

The titled compound was prepared following the procedure E using 6-({4-[(4-chlorophenyl)ethynyl]benzyl}amino)-2,2-dimethyl-4H-1,3-benzodioxin-4-one and 3-fluorobenzoyl chloride as a yellow oil (96%). M+ (ESI): 540.2. HPLC, Rt: 5.71 min (Purity: 97.4%).

Sources & evidence

ORD record
ord-71c98fbd65e943999e1340b42f44e1f9
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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